首页|Light-Driven Cobalt Hydride Catalyzed Hydroarylation of Styrenes
Light-Driven Cobalt Hydride Catalyzed Hydroarylation of Styrenes
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We report a conceptually distinct strategy for the synthesis of 1,1-diarylalkanes and triarylalkanes. Key to this approach is the use of light to simultaneously trigger (i) formation of a CoIII-H species which undergoes H atom transfer (MHAT) to styrenes, giving a carbon-centered radical, and (ii) generation of a persistent (hetero)arene radical. Selective coupling of these two species yields Markovnikov hydroarylation products under mild conditions and without precious metals. In contrast to many previous approaches, electron-defficient (hetero)arene coupling partners are favored and it is possible to construct highly congested quaternary centers, including those with three different aryl groups.
cobalthydroarylationhydrogen atom transferMHAT catalysisphotocatalysisphotochemistryHantzsch esterorganic hydride donor
Enrico Bergamaschi、Victor J. Mayerhofer、Christopher J. Teskey
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Institute of Organic Chemistry, RWTH Aachen University, 52074 Aachen, Germany
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