The roles of microRNAs related with progression and metastasis in human cancers
Liu, Hai-Ting 1Gao, Peng1
扫码查看
点击上方二维码区域，可以放大扫码查看
作者信息
1. Shandong Univ, Qilu Hosp, Dept Pathol, Jinan, Peoples R China
折叠
Abstract
Metastasis is an important factor in predicting the prognosis of the patients with cancers and contributes to high cancer-related mortality. Recent studies indicated that microRNAs (miRNAs) played a functional role in the initiation and progression of human malignancies. MicroRNAs are small non-coding RNAs of about 22 nucleotides in length that can induce messenger RNA (mRNA) degradation or repress mRNA translation by binding to the 3' untranslated region (3'-UTR) of their target genes. Overwhelming reports indicated that miRNAs could regulate cancer invasion and metastasis via epithelial-to-mesenchymal transition (EMT)-related and/or non-EMT-related mechanisms. In this review, we concentrate on the underlying mechanisms of miRNAs in regulating cancer progression and metastasis.
NSTL
Sage