The kappa opioid receptor may be a potential tumor suppressor by regulating angiogenesis in breast cancer
Shi, Yumiao 1Luo, Jiamei 1Tian, Jie 1Zou, Qiaoqun 1Wang, Xiaoqiang1
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作者信息
1. Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Anesthesiol, Shanghai 200127, Peoples R China
折叠
Abstract
Our hypothesis proposes that activating x-opioid receptors (KORs) may inhibit the progression of breast cancer and improve patient prognosis. Consequently, KORs may become a promising therapeutic target for breast cancer. Activating KORs induces not only analgesic efficacy comparable to ?-opioid receptors but also shows a promising antitumor effect and with fewer opioid-induced adverse effects. Based on present studies and our bioinformatics analysis of KORs, we propose that KORs can function as a tumor suppressor by inhibiting angiogenesis in human breast cancer; therefore, analgesics that mainly activate KORs would be more suitable for breast cancer patients.
NSTL
Elsevier