首页|Alteration of gamma-aminobutyric acid in the left dorsolateral prefrontal cortex of individuals with chronic insomnia: a combined transcranial magnetic stimulation-magnetic resonance spectroscopy study

Alteration of gamma-aminobutyric acid in the left dorsolateral prefrontal cortex of individuals with chronic insomnia: a combined transcranial magnetic stimulation-magnetic resonance spectroscopy study

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  • NSTL
  • Elsevier
Objective: To investigate changes in the level of gamma-aminobutyric acid (GABA) in the left dorsolateral prefrontal cortex (DLPFC) of patients with chronic insomnia treated with real repetitive transcranial magnetic stimulation (rTMS) as compared to sham-rTMS, as measured with H-1-Magnetic Resonance Spectroscopy (H-1-MRS). Methods: Forty chronic insomnia participants were randomized to either real or sham rTMS group. The rTMS was administered once per day Continuously for 14 days with the stimulation over the left DLPFC. Left DLPFC GABA level relative to creatine (Cr) was measured by H-1-MRS. Insomnia symptom was evaluated by Insomnia Severity Index (ISI). MRS and ISI were assessed among all participants before and after treatment. This study was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100047255). Results: After treatment, the ISI score in real rTMS group was markedly decreased as compared to prerTMS (t =-4.25, p < 0.001, Cohen's d = 0.90), whereas no significant change in ISI was observed in the group of sham rTMS. In addition, we observed a significant increase of GABA+/Cr concentration in the real rTMS group after stimulation (0.37 +/- 0.11 to 0.40 +/- 0.11, p = 0.039), but that of sham did not (0.38 +/- 0.10 to 0.39 +/- 0.11, p = 0.151). However, there was no significant association between the change of GABA+/Cr in left DLPFC and the changes of ISI scores in the two groups. Conclusion: 1 Hz rTMS has the potential to increase GABA + level in left DLPFC of patients with chronic insomnia, and warrants further investigation. (c) 2022 The Authors. Published by Elsevier B.V.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Repetitive transcranial magnetic&nbspstimulationProton magnetic resonance spectroscopyChronic insomniaGamma-aminobutyric acidMAJOR DEPRESSIVE DISORDERSEVERITY INDEXCORTICAL EXCITABILITYMEGA-PRESSGABAPATHOPHYSIOLOGYVALIDATIONMANAGEMENTGLUTAMATEEFFICACY

Zhang, Huashuang、Huang, Xiaowei、Wang, Chen、Liang, Kangfu

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Inst Brain Res & Rehabil IBRR,South China Normal Univ

Diagnost Imaging Ctr,Puning Overseas Chinese Hosp

Coll Nursing,Wuchang Univ Technol

Affiliated Foshan Hosp,Southern Med Univ

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2022

10.1016/j.sleep.2022.03.003

Sleep medicine

Sleep medicine

SCI
ISSN：1389-9457
年,卷(期)：2022.92
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