Tetrahedron letters2022，Vol.895.DOI:10.1016/j.tetlet.2021.153603

Electronic effect control of regioselectivity in the Michael-Addition inspired cascade reaction of 1,3-dimethyl-6-amino-uracil and 2-hydroxychalcones

Cui X. Lin J.-J. Wang S. Li J.-P. Huang C. Xia X.-S.
Tetrahedron letters2022，Vol.895.DOI:10.1016/j.tetlet.2021.153603
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  • NSTL
  • Elsevier

Electronic effect control of regioselectivity in the Michael-Addition inspired cascade reaction of 1,3-dimethyl-6-amino-uracil and 2-hydroxychalcones

Cui X. 1Lin J.-J. 1Wang S. 1Li J.-P. 1Huang C. 1Xia X.-S.2
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作者信息

  • 1. School of Chemistry and Environment Yunnan Minzu University
  • 2. Teaching Affairs Department Yunnan University of Chinese Medicine
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Abstract

? 2021 Elsevier LtdAn unexpected Brosnted acid-catalyzed cascade reaction of 1,3-dimethyl-6-aminouracil with 2-hydroxychalcone has been developed to afford pyrido[2,3–d]pyrimidine-2,4-diones derivatives and 2,8-dioxabicyclo[3.3.1]nonane derivatives in moderate to good yields. This method not only establishes a new transformation of 1,3-dimethyl-6-amino-uracil and 2-hydroxychalcone but also provides an efficient method for the synthesis of pyrido[2,3–d]pyrimidine-2,4-diones and 2,8-dioxabicyclo[3.3.1]nonane derivatives.

Key words

2/8-dioxabicyclo[3.3.1]nonane derivatives/Cascade reaction/Electronic effect/Metal-free catalyst/Pyrido[2/3–d]pyrimidine-2/4-diones derivatives

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量1
参考文献量22
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