首页|microRNA-144 modulates the NF-?B pathway in miiuy croaker (Miichthys miiuy) by targeting I?Ba gene
microRNA-144 modulates the NF-?B pathway in miiuy croaker (Miichthys miiuy) by targeting I?Ba gene
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NSTL
Elsevier
MicroRNAs (miRNA) are non-coding RNAs that regulate many biochemical processes, such as cell growth, proliferation and immune responses. In this study, we investigated miR-144 as a regulator of I kappa B alpha that promotes the activation of NF-kappa B signaling pathway. And I kappa B alpha interact with p65 blocks nuclear translocation of NF-kappa B and anchors NF-kappa B in cytoplasmic quiescent cells in an inactive form. The seed region of miR-144 can regulate gene expression by binding to the 3' UTR of I kappa B alpha and repress I kappa B alpha expression at the post-transcriptional level. More importantly, miR-144 can promote the activation of p65 by inhibiting I kappa B alpha, thus affecting the NF-kappa B signaling pathway. Thus, preventing excessive inflammatory responses from causing autoimmune diseases will help to further understand the immunoregulatory mechanisms of miRNAs in fish after invasion by pathogens.
NSTL
Elsevier
