首页|Performance and selectivity of amphiphilic pillar[5]arene as stationary phase for capillary gas chromatography
Performance and selectivity of amphiphilic pillar[5]arene as stationary phase for capillary gas chromatography
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NSTL
Elsevier
Pillar[n]arenes possess highly symmetrical and rigid pillar-shaped architecture with pi-electron rich cavity that afford their reliable host-guest recognition interactions towards matched guests. In this work, a novel amphiphilic pillar[5]arene (P5A-C10-2NH(2)) was designed, synthesized and employed as the stationary phase for capillary gas chromatography. To date, they have not been reported in the field of chromatography. The P5A-C10-2NH(2) capillary column (10 m x 0.25 mm i.d.) was prepared by static coating method. Its capillary column exhibited moderate polarity and column efficiency of 2265 plates/m determined by naphthalene at 120 degrees C. As evidenced, the P5A-C10-2NH(2) column achieved advantageous separation performance for a mixture of 24 analytes of diverse types and exhibited different chromatographic selectivity from two pillar[5]arene derivatives columns and commercial HP-35 column with 35%-phenyl-methylpolysiloxane. Moreover, the P5A-C10-2NH(2) column baseline resolved more than a dozen positional and cis-trans isomers. Furthermore, the separation mechanism of P5A-C10-2NH(2) column was discussed by quantum chemical calculations. In addition, the P5A-C10-2NH(2) column had high thermal stability and excellent separation repeatability 0.01-0.04% for run-to-run, 0.03-0.17% for day-to-day and 3.2-3.9% for column-to-column. The special amphiphilic structure and high resolution for various analytes reveal the good potential of pillararenes as a new class of stationary phases for chromatographic analyses. Moreover, the TPG column achieved improved thermal stability over the GIL column and excellent repeatability. (c) 2022 Elsevier B.V. All rights reserved.
Capillary gas chromatographyStationary phaseSeparationPillar[n]arenesIONIC LIQUIDSCYCLODEXTRINSCOLUMNS
NSTL
Elsevier
