首页|Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin

Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin

扫码查看
原文链接
  • NSTL
  • Elsevier
Daily new information emerges regarding the COVID-19， infection of SARS-CoV-2， which is considered a global pandemic。 Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are required to complete the viral invasion pathway and are present in the oral mucosa， gingiva and periodontal pocket。 Thus， increasing the likelihood of periodontitis and gingivitis caused by COVID-19。 The cytokine storm during COVID-19 similarly arises during periodontal inflammation。 Studies have reported that NOD-Like Receptor family pyrin domain-containing 3 (NLRP3) inflammasome is significant in the cytokine storm。 Recently， the course of the COVID-19 has been related to the melatonin levels in both COVID-19 and periodontal diseases。 It is known that melatonin prevents the activation of NLRP3 inflammasome。 In light of these findings， we think that melatonin treatment during COVID-19 or periodontal diseases may prevent the damage seen in periodontal tissues by preventing the activation of NLRP3 inflammasome。

COVID-19MelatoninNLRP3PeriodontitisSARS-CoV-2

Sehirli, Ahmet Ozer、Aksoy, Umut、Koca-Unsal, Revan Birke、Sayiner, Serkan

展开 >

Near East Univ, Fac Dent, Dept Pharmacol, CY-99138 Nicosia, Cyprus

Near East Univ, Fac Dent, Dept Endodont, CY-99138 Nicosia, Cyprus

Univ Kyrenia, Fac Dent, Dept Periodontol, CY-99320 Kyrenia, Cyprus

Near East Univ, Fac Vet Med, Dept Biochem, CY-99138 Nicosia, Cyprus

展开 >

2021

10.1016/j.mehy.2021.110588

Medical hypotheses

Medical hypotheses

SCI
ISSN：0306-9877
年,卷(期)：2021.151
  • 4
  • 49