首页|Biodegradable nano-porous Mn3O4 with sustainable release for improving the stability and bioactivity of peptide RVPSL
Biodegradable nano-porous Mn3O4 with sustainable release for improving the stability and bioactivity of peptide RVPSL
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NSTL
Elsevier
Food-derived bioactive peptides have drawn much attention because of their health-promoting benefits. The previous study has demonstrated that bioactive peptide RVPSL could be considered a possible food ingredient. However due to low stability and bioavailability in the gastrointestinal tract limit its application in the food industry. Thus, a biodegradable nano-porous Mn3O4 based on the two-dimensional sacrificial template graphene oxide was synthesized to improve the stability of RVPSL in the gastrointestinal tract. The size of the porous Mn3O4 was approximately 50-150 nm with 5-15 nm pores, and exhibited a high surface area (38.62 m(2)/g) result to high loading capacity of RVPSL (0.43 mg/1 mg). More importantly, the stability of RVPSL was improved after loaded to the porous Mn3O4. The cumulative release of the functional composite Mn3O4/RVPSL was 31.16% after 120 h incubated in pH 7.4. Furthermore, the bioactivity of peptide RVPSL was improved about 32% after 7 h simulated digestion. In conclusion, the current study demonstrated that the porous Mn3O4 nanoparticle could be considered as a potential strategy for the delivery of bioactive compounds with improved functional attributes.
NSTL
Elsevier
