首页|Stepped Wedge Cluster Randomized Trials: A Methodological Overview

Stepped Wedge Cluster Randomized Trials: A Methodological Overview

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  • NSTL
  • Elsevier
? 2021 Elsevier Inc.Background: Stepped wedge cluster randomized trials enable rigorous evaluations of health intervention programs in pragmatic settings. In the present study, we aimed to update neurosurgeon scientists on the design of stepped wedge randomized trials. Methods: We have presented an overview of recent methodological developments for stepped wedge designs and included an update on the newer associated methodological tools to aid with future study designs. Results: We defined the stepped wedge trial design and reviewed the indications for the design in depth. In addition, key considerations, including mainstream methods of analysis and sample size determination, were discussed. Conclusions: Stepped wedge designs can be attractive for study intervention programs aiming to improve the delivery of patient care, especially when examining a small number of heterogeneous clusters.

Cluster randomized trialsIntraclass correlation coefficientMethodological reviewSample size determinationStatistical softwareStepped wedge design

Li F.、Wang R.

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Department of Biostatistics Yale University School of Public Health

Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute

2022

10.1016/j.wneu.2021.10.136

World neurosurgery

World neurosurgery

SCI
ISSN：1878-8750
年,卷(期)：2022.161
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