Abstract
? 2022 Elsevier B.V.Gold nanorods (Au NRs)/Ti3C2Tx composites were prepared by self-assembly method as surface enhanced Raman scattering (SERS) substrates. Due to strong electrostatic interaction, Au NRs are evenly arranged on the surface of Ti3C2Tx nanosheets, forming rich SERS hotspots. Au NRs/Ti3C2Tx have high sensitivity and good reproducibility for the determination of organic dyes such as rhodamine 6G, crystal violet and malachite green. The detection limits were 1 × 10?13, 1 × 10?13 and 1 × 10?12 M, respectively. The relative standard deviations of samples in 40 areas were 4.57 %, 2.79 % and 3.47 %, respectively. The synthesized SERS substrate is sensitive to adenine. For adenine molecules in the range of 1 × 10?5–1 × 10?9 M, SERS results show that the peak intensity is linear with adenine molecular concentration, and the detection limit can be as low as 1 × 10?9 M. In addition, adenine in aqueous solution has good anti-interference ability to other nucleic acids with similar structure, such as guanine, cytosine and thymine. Therefore, Au NRs/Ti3C2Tx are expected to become a potential substrate for unmarked, rapid and sensitive SERS detection of adenine in the field of bioanalysis.
NSTL