Pharmacological Properties of 2-Aminobenzimidazole Halides and Imidazo[1,2-a]Benzimidazole Derivatives

Spasov, A. A. Zhukovskaya, O. N. Gurova, N. A. Naumenko, L. V. Eliseeva, N. V. Kucheryavenko, A. F. Kosolapov, V. A. Yakovlev, D. S. Muravyeva, V. Y. Babkova, V. A. Babkov, D. A. Lifanova, J. V. Morkovnik, A. S.

Russian journal of bioorganic chemistry2022，Vol.48Issue(2) ：11.DOI:10.1134/S1068162022020236

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NSTL
Springer Nature

Pharmacological Properties of 2-Aminobenzimidazole Halides and Imidazo[1,2-a]Benzimidazole Derivatives

Spasov, A. A. ¹Zhukovskaya, O. N. ²Gurova, N. A. ¹Naumenko, L. V. ¹Eliseeva, N. V. ¹Kucheryavenko, A. F. ¹Kosolapov, V. A. ¹Yakovlev, D. S. ¹Muravyeva, V. Y. ¹Babkova, V. A. ¹Babkov, D. A. ¹Lifanova, J. V. ¹Morkovnik, A. S.²

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作者信息

1. Southern Fed Univ
2. Volgograd Med Sci Ctr
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Abstract

Halides of 2-aminobenzimidazolium and derivatives of 9-substituted 2-(4-fluorophenyl)imidazo[1,2-a]benzimidazoles have been studied for ten types of biological activity in vitro. Among the aminobenzimidazolium derivatives, a compound with NHE-1 inhibitory activity has been identified. It has been demonstrated that imidazobenzimidazole derivatives affect the duration of the refractory period of rat atria, platelet aggregation, and hemorheological activity and inhibit the formation of end products of glycation. No DPP-4 inhibitory, antioxidant, kappa-opioid, and 5-HT2A and 5-HT3 antagonistic activities have been found among the studied compounds.

Key words

imidazo[1/2-a]benzimidazole/2-aminobenzimidazolium halides/NHE-1 inhibitory activity/antiplatelet action/hemorheological activity/antiglycating effect/PRIVILEGED STRUCTURES

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出版年

2022

Russian journal of bioorganic chemistry

SCI

ISSN：1068-1620

被引量1

参考文献量24

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