首页|Subtle Cognitive Deficits Are Associated with Amyloid-β Positivity, but Not Severity of Self-Reported Decline: Results from the CoSCo Study

Subtle Cognitive Deficits Are Associated with Amyloid-β Positivity, but Not Severity of Self-Reported Decline: Results from the CoSCo Study

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Introduction: Subjective cognitive decline (SCD) can be considered as the preclinical manifestation of Alzheimer’s disease (AD). The National Institute on Aging and the Alzheimer’s Association criteria for preclinical AD proposed that subtle cognitive changes appear along with AD biomarkers in the late stage of preclinical AD. The objective of this study was to explore whether subtle cognitive impairment (SCI) in individuals with SCD is associated with brain amyloid-β (Aβ) status and SCD severity. Methods: One hundred twenty individuals with SCD (mean age: 70.87 ± 6.10 years) were included in this study. SCI was defined as performance ≤ ?1.0 SD on at least two neuropsychological tests. Participants underwent an amyloid positron emission tomography, which was assessed visually and quantitatively using standardized uptake value ratio (SUVR). The severity of SCD was assessed using two self-reported questionnaires: the SCD questionnaire based on the SCD-plus features and the Korean-Everyday Cognition (K-ECog) scale. Results: SCD individuals with SCI (n = 25) had more Aβ positivity than the SCD only group (n = 95) (44% vs. 15.79%; p = 0.002). In addition, the SCI group had a higher global SUVR than the SCD only group (p = 0.048). For self-reported questionnaires, there were no differences in SCD questionnaire total scores and K-ECog global and cognitive domain-specific scores between two groups. Conclusions: In SCD individuals, SCI was associated with higher Aβ positivity, but not with the severity of self-reported cognitive decline, compared to the SCD only group. These results suggest that the recognition of objectively defined subtle cognitive deficits may contribute to the early identification of AD in SCD.

Subjective cognitive declineSubtle cognitive impairmentAmyloid-βAlzheimer’s disease

Seon Young,Ryu、Yun Jeong,Hong、SeongHee,Ho、Jee Hyang,Jeong、Kee Hyung,Park、SangYun,Kim、Min Jeong,Wang、Seong Hye,Choi、Dong Won,Yang

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Department of Neurology, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University

Department of Neurology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic

Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of

Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of

Department of Neurology, College of Medicine, Gachon University Gil Medical Center, Incheon

Department of Neurology, Seoul National University College of Medicine &amp

Clinical Neuroscience

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2022

10.1159/000523971

Dementia and geriatric cognitive disorders

Dementia and geriatric cognitive disorders

SCI
ISSN：1420-8008
年,卷(期)：2022.51(2)
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