首页|Obstructive sleep apnoea is associated with the development of diastolic dysfunction after myocardial infarction with preserved ejection fraction
Obstructive sleep apnoea is associated with the development of diastolic dysfunction after myocardial infarction with preserved ejection fraction
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Elsevier
Background: Left ventricular diastolic dysfunction is a predictor of adverse outcome after acute myocardial infarction (AMI). We aimed to test if sleep-disordered breathing (SDB) contributes to the development of diastolic dysfunction in patients with preserved left ventricular ejection fraction after AMI. Method: Patients with AMI, percutaneous coronary intervention and an ejection fraction >= 50% were included in this sub-analysis of a prospective observational study. Patients with AMI (n = 41) underwent cardiovascular magnetic resonance imaging (volume-time curve analysis) to define diastolic function by means of the normalised peak filling rate [nPFR; (end diastolic volume/second)]. In patients with AMI, the nPFR was assessed within <5 days and three months after AMI. Patients with AMI were stratified in patients with (apnoea-hypopnoea index, AHI >= 15/h) and without (AHI <15/h) SDB as assessed by polysomnography. Results: At the time of AMI, the nPFR was similar between patients with and without SDB (2.90 +/- 0.54 vs. 3.03 +/- 1.20, p = 0.662). Within three months after AMI, diastolic function was significantly lower in patients with SDB than in patients without SDB (AnPFR: -0.83 +/- 0.14 vs. 0.03 +/- 0.14; p < 0.001; ANCOVA, adjusted for baseline nPFR). In contrast to central AHI, obstructive AHI was associated with a lower nPFR three months after AMI, after accounting for established risk factors for diastolic dysfunction [multiple linear regression analysis, B (95%CI): -0.036 (-0.063 to -0.009), p = 0.011]. Conclusion: Our data indicate that obstructive sleep apnoea impairs diastolic function early after myocardial infarction. (C) 2022 The Authors. Published by Elsevier B.V.
NSTL
Elsevier
