首页|Pinellic Acid Isolated from Quercetin-rich Onions has a Peroxisome Proliferator-Activated Receptor-Alpha/Gamma (PPAR-α/γ) Transactivation Activity

Pinellic Acid Isolated from Quercetin-rich Onions has a Peroxisome Proliferator-Activated Receptor-Alpha/Gamma (PPAR-α/γ) Transactivation Activity

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  • NSTL
  • Thieme Medical Publishers
Quercetin, a flavonol, is a functional compound that is abundant in onions and is known to have antioxidant and anti-inflammatory effects. Quercetin and its glucoside are known to function as peroxisome proliferator-activated receptor (PPAR) ligands and showed high PPAR-α transactivation activity but little PPAR-γ transactivation activity in some reports. In this study, we demonstrated that an aqueous extract of a quercetin-rich onion cultivar increased transactivation activities not only of PPAR-α but also of PPAR-γ. We isolated (9S,12S,13S)-(10E)-9,12,13-trihydroxyoctadec-10-enoic acid (pinellic acid) obtained from the aqueous extract using PPAR-γ transactivation as an index. Furthermore, it was revealed that pinellic acid could transactivate PPAR-α. Our findings are the first report mentioned showing that trihydroxyoctadec-10-enoic acids showed PPAR-α/γ transactivation activities.

Allium cepaAmaryllidaceae(9S12S13S)-(10E)-91213-Trihydroxyoctadec-10-enoic acid (Pinellic acid)(S) configurationperoxisome proliferator-activated receptornuclear factor-κB

Satoru Ohgiya、Daisaku Okamoto、Kenichi Sato、Yukiya Ito、Hideyuki Matsuura、Yasuyuki Hashidoko、Mikio Doi、Naoki Morita、Tsugumi Okuzawa

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National Institute of Advanced Industrial Science and Technology, AIST Hokkaido, Hokkaido

Plant Breeding Institute, Hokkaido

Northern Advancement Center for Science and Technology, Hokkaido

Graduate School of Agriculture, Hokkaido University

Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology

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2022

10.1055/a-1345-9471

Planta medica

Planta medica

SCI
ISSN：0032-0943
年,卷(期)：2022.88(6)
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