首页|Tandem Copper(I)‐Catalyzed N‐Arylation–1,4‐Conjugate Addition to Access Tetrahydroacridinones
Tandem Copper(I)‐Catalyzed N‐Arylation–1,4‐Conjugate Addition to Access Tetrahydroacridinones
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NSTL
Wiley
Abstract A copper‐catalyzed tandem process integrating N‐arylation and 1,4‐conjugate addition is disclosed through the reaction of cyclic enaminones and ortho‐halochalcones. The reaction appears to proceed through chemoselective arylation on the nitrogen of enaminone with ortho‐halochalcones and Michael addition of α‐carbon of the enaminone to the chalcone to furnish a diverse range of tricyclic tetrahydroacridinone derivatives in moderate to excellent yields.
Tandem reactionCopper catalysisN-ArylationMichael additionAcridinone derivatives
Jyoti M. Honnanayakanavar、Purna Chandra Behera、Surisetti Suresh
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CSIR-Indian Institute of Chemical Technology (CSIR-IICT)
NSTL
Wiley
