首页|Iridoids and lignans from Valeriana officinalis L. and their cytotoxic activities

Iridoids and lignans from Valeriana officinalis L. and their cytotoxic activities

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeTwo new iridoids (1 and 2), one new lignan (3) together with one known iridoid (4) and twelve known lignans (5－16) were obtained from the roots of Valeriana officinalis L. (V. officinalis). The structures were determined using IR, MS, 1D and 2D NMR spectroscopy and the absolute configurations of the new structures were deduced by ECD experiments. All of the isolated compounds were assayed for their cytotoxic activities against three tumour cell lines (A549, HCT116 and SW620) and the results showed that compounds 9 and 10 showed cytotoxicities against A549 cells, compounds 9 and 11 showed cytotoxicities against SW620 cells and compound 10 showed cytotoxicities against HCT116 cells.

Cytotoxic activitiesIridoidsLignansStructure determinationValeriana officinalis L.

Zhang Z.、Zhang D.、Wu G.、Sun Y.、Jiang Y.、Zhang H.、Wang W.、Song X.、Li Y.

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School of Pharmacy Shaanxi University of Chinese Medicine

2022

10.1016/j.phytol.2022.03.018

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.49
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