首页|Decorin as a possible strategy for the amelioration of COVID-19

Decorin as a possible strategy for the amelioration of COVID-19

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  • NSTL
  • Elsevier
Coronavirus pandemic has emerged as an extraordinary healthcare crisis in modern times。 The SARS-CoV-2 novel coronavirus has high transmission rate， is more aggressive and virulent in comparison to previously known coronaviruses。 It primarily attacks the respiratory system by inducing cytokine storm that causes systemic inflammation and pulmonary fibrosis。 Decorin is a pluripotent molecule belonging to a leucine rich proteoglycan group that exerts critical role in extracellular matrix (ECM) assembly and regulates cell growth， adhesion， proliferation， inflammation， and fibrogenesis。 Interestingly， decorin has potent anti-inflammatory， cytokine inhibitory， and anti-fibrillogenesis effects which make it a potential drug candidate against the COVID-19 related complications especially in the context of lung fibrosis。 Herein， we postulate that owing to its distinctive pharmacological actions and immunomodulatory effect， decorin can be a promising preclinical therapeutic agent for the therapy of COVID-19。

DecorinCOVID-19Lung injuryFibrosisImmunomodulation

Allawadhi, Prince、Singh, Vishakha、Khurana, Isha、Rawat, Pushkar Singh、Renushe, Akshata Patangrao、Khurana, Amit、Navik, Umashanker、Allwadhi, Sachin、Karlapudi, Satish Kumar、Banothu, Anil Kumar、Bharani, Kala Kumar

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Pandit Bhagwat Dayal Sharma Univ Hlth Sci Pt BDS, Vaish Inst Pharmaceut Educ & Res VIPER, Dept

Indian Inst Technol IIT Roorkee, Dept Biotechnol, Roorkee 247667, Uttarakhand, India

Panjab Univ, Univ Inst Pharmaceut Sci UIPS, Dept Pharmaceut Chem, Chandigarh 160014, India

Cent Univ Punjab, Sch Basic & Appl Sci, Dept Pharmacol, Bathinda 151401, Punjab, India

PVNRTVU, Dept Vet Pharmacol & Toxicol, Coll Vet Sci CVSc, Hyderabad 500030, Telangana, India

Maharshi Dayanand Univ MDU, Univ Inst Engn & Technol UIET, Dept Comp Sci & Engn, Rohtak 124001

PVNRTVU, Dept Vet Med, Coll Vet Sci CVSc, Hyderabad 500030, Telangana, India

PVNRTVU, Dept Aquat Anim Hlth Management, Coll Fishery Sci, Wanaparthy 509104, Telangana, India

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2021

10.1016/j.mehy.2021.110612

Medical hypotheses

Medical hypotheses

SCI
ISSN：0306-9877
年,卷(期)：2021.152
  • 8
  • 61