Medical hypotheses2021，Vol.1526.DOI:10.1016/j.mehy.2021.110612

Decorin as a possible strategy for the amelioration of COVID-19

Allawadhi, Prince Singh, Vishakha Khurana, Isha Rawat, Pushkar Singh Renushe, Akshata Patangrao Khurana, Amit Navik, Umashanker Allwadhi, Sachin Karlapudi, Satish Kumar Banothu, Anil Kumar Bharani, Kala Kumar
Medical hypotheses2021，Vol.1526.DOI:10.1016/j.mehy.2021.110612
✕
  • NSTL
  • Elsevier

Decorin as a possible strategy for the amelioration of COVID-19

Allawadhi, Prince 1Singh, Vishakha 2Khurana, Isha 3Rawat, Pushkar Singh 4Renushe, Akshata Patangrao 5Khurana, Amit 5Navik, Umashanker 4Allwadhi, Sachin 6Karlapudi, Satish Kumar 7Banothu, Anil Kumar 5Bharani, Kala Kumar8
扫码查看

作者信息

  • 1. Pandit Bhagwat Dayal Sharma Univ Hlth Sci Pt BDS, Vaish Inst Pharmaceut Educ & Res VIPER, Dept
  • 2. Indian Inst Technol IIT Roorkee, Dept Biotechnol, Roorkee 247667, Uttarakhand, India
  • 3. Panjab Univ, Univ Inst Pharmaceut Sci UIPS, Dept Pharmaceut Chem, Chandigarh 160014, India
  • 4. Cent Univ Punjab, Sch Basic & Appl Sci, Dept Pharmacol, Bathinda 151401, Punjab, India
  • 5. PVNRTVU, Dept Vet Pharmacol & Toxicol, Coll Vet Sci CVSc, Hyderabad 500030, Telangana, India
  • 6. Maharshi Dayanand Univ MDU, Univ Inst Engn & Technol UIET, Dept Comp Sci & Engn, Rohtak 124001
  • 7. PVNRTVU, Dept Vet Med, Coll Vet Sci CVSc, Hyderabad 500030, Telangana, India
  • 8. PVNRTVU, Dept Aquat Anim Hlth Management, Coll Fishery Sci, Wanaparthy 509104, Telangana, India
  • 折叠

Abstract

Coronavirus pandemic has emerged as an extraordinary healthcare crisis in modern times. The SARS-CoV-2 novel coronavirus has high transmission rate, is more aggressive and virulent in comparison to previously known coronaviruses. It primarily attacks the respiratory system by inducing cytokine storm that causes systemic inflammation and pulmonary fibrosis. Decorin is a pluripotent molecule belonging to a leucine rich proteoglycan group that exerts critical role in extracellular matrix (ECM) assembly and regulates cell growth, adhesion, proliferation, inflammation, and fibrogenesis. Interestingly, decorin has potent anti-inflammatory, cytokine inhibitory, and anti-fibrillogenesis effects which make it a potential drug candidate against the COVID-19 related complications especially in the context of lung fibrosis. Herein, we postulate that owing to its distinctive pharmacological actions and immunomodulatory effect, decorin can be a promising preclinical therapeutic agent for the therapy of COVID-19.

Key words

Decorin/COVID-19/Lung injury/Fibrosis/Immunomodulation

引用本文复制引用

出版年

2021
Medical hypotheses

Medical hypotheses

SCI
ISSN：0306-9877
被引量8
参考文献量61
段落导航相关论文