首页|Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies

Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies

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  • NSTL
  • Elsevier
Preeclampsia is a syndromic disease of the mother, fetus, and placenta. The main limitation in early and accurate diagnosis of preeclampsia is rooted in the heterogeneity of this syndrome as reflected by diverse molecular pathways, symptoms, and clinical outcomes. Gaps in our knowledge preclude successful early diagnosis, personalized treatment, and prevention. The advent of ???omics??? technologies and systems biology approaches addresses this problem by identifying the molecular pathways associated with the underlying mechanisms and clinical phenotypes of preeclampsia. Here, we provide a brief overview on how the field has progressed, focusing on studies utilizing state-of-the-art transcriptomics and proteomics methods. Moreover, we summarize our systems biology studies involving maternal blood proteomics and placental transcriptomics, which identified early maternal and placental disease pathways and showed that their interaction influences the clinical presentation of preeclampsia. We also present an analysis of maternal blood proteomics data which revealed distinct molecular subclasses of preeclampsia and their molecular mechanisms. Maternal and placental disease pathways behind these subclasses are similar to those recently reported in studies on the placental transcriptome. These findings may promote the development of novel diagnostic tools for the distinct subtypes of preeclampsia syndrome, enabling early detection and personalized follow-up and tailored care of patients.

Class discoveryGreat obstetrical syndromesHigh-dimensional biologyLiquid biopsy?Omics ? sciencesPersonalized medicinePrenatal diagnosisLATE-ONSET PREECLAMPSIAPLACENTAL GENE-EXPRESSIONUTERINE ARTERY DOPPLERANGIOGENIC FACTORSGESTATIONAL-AGEEXTRACELLULAR VESICLESSOLUBLE ENDOGLINPOTENTIAL ROLEGROWTH-FACTORPREGNANCY

Than, Nandor Gabor、Posta, Mate、Gyorffy, Daniel、Orosz, Laszlo、Orosz, Gergo、Rossi, Simona W.、Ambrus-Aikelin, Geza、Szilagyi, Andras、Nagy, Sandor、Hupuczi, Petronella、Torok, Olga、Tarca, Adi L.、Erez, Offer、Papp, Zoltan、Romero, Roberto

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Inst Enzymol,Res Ctr Nat Sci

Dept Obstet & Gynecol,Univ Debrecen

Genesis Theranostix Grp

Fac Hlth & Sport Sci,Szechenyi Istvan Univ

Matern Private Clin Obstet & Gynecol

Perinatol Res Branch,Eunice Kennedy Shriver NICHHD

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2022

10.1016/j.placenta.2022.03.009

Placenta

Placenta

ISTP
ISSN：0143-4004
年,卷(期)：2022.125
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