首页|Insulin-signaling abnormalities in drug-naive first-episode schizophrenia: Transduction protein analyses in extracellular vesicles of putative neuronal origin

Insulin-signaling abnormalities in drug-naive first-episode schizophrenia: Transduction protein analyses in extracellular vesicles of putative neuronal origin

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  • NSTL
  • Cambridge Univ Press
Background: Metabolic syndrome and impaired insulin sensitivity may occur as side effects of atypical antipsychotic drugs. However, studies of peripheral insulin resistance using the homeostatic model assessment of insulin resistance (HOMA-IR) or oral glucose tolerance tests (OGTT) suggest that abnormal glucose metabolism is already present in drug-naive first-episode schizophrenia (DNFES). We hypothesized impairments of neuronal insulin signaling in DNFES.

SchizophreniaPsychosisMolecular biologyExosomesInsulinSerine-threonine kinasesAKTGSK3 betamTORp70S6KIRS-1

Kapogiannis, Dimitrios、Dobrowolny, Henrik、Tran, Joyce、Mustapic, Maja、Frodl, Thomas、Meyer-Lotz, Gabriela、Schiltz, Kolja、Schanze, Denny、Rietschel, Marcella、Bernstein, Hans-Gert、Steiner, Johann

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NIA, Lab Neurosci, Natl Inst Hlth NIA NIH, Baltimore, MD 21224 USA

Otto von Guericke Univ, Dept Psychiat & Psychotherapy, Magdeburg, Germany

Otto von Guericke Univ, Inst Human Genet, Magdeburg, Germany

Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim

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2019

10.1016/j.eurpsy.2019.08.012

European psychiatry :

European psychiatry :

ISSN：0924-9338
年,卷(期)：2019.62
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