首页|Fabrication of zein and κ-carrageenan colloidal particles for encapsulation of quercetin: In-vitro digestibility and bio-potential activities
Fabrication of zein and κ-carrageenan colloidal particles for encapsulation of quercetin: In-vitro digestibility and bio-potential activities
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NSTL
Elsevier
? 2022 The Korean Society of Industrial and Engineering ChemistryThe present work aims to prepare and stabilize quercetin (Q) loaded zein colloidal nanoparticles using κ-carrageenan (KC) as a stabilizer. Antisolvent precipitation method was used to fabricate the zein-KC colloidal nanoparticles at pH 5.0. The findings revealed that the newly prepared Q-loaded zein-KC complex colloidal particles had spherical shapes, a particle size below ～300.0 nm, a high magnitude of negative zeta potential (～?45.0 mV) and encapsulation efficiency of 62.0%. The molecular interactions among zein, Q and KC in colloidal particles were confirmed by FT-IR analysis, and the combined mixture showed an amorphous diffraction pattern during the XRD analysis without revealing the crystalline peaks of Q or KC, indicating that Q was effectively encapsulated in complex colloidal particles. In aqueous environments, the anionic KC coating on the surface of zein colloidal particles modified the particulate and physicochemical properties of the encapsulated Q and enhanced its water dispersibility, thermal stability, and in-vitro release. The observed improvements were ascribed to hydrogen bonding, hydrophobic and electrostatic interactions among Q, zein, and KC. In addition, Q-loaded zein-KC complex colloidal particles demonstrated strong antioxidant activity. The results of this study revealed that, the KC coated zein colloidal particles, therefore, have great potential for use in hydrophobic nutraceutical encapsulation.
NSTL
Elsevier
