首页|Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity

Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity

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  • NSTL
  • Elsevier
? 2022 Elsevier LtdTwenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglyptin A was the most active with IC50 values of 16.34, 15.63 and 21.33 μM and was further investigated for colony formation and apoptosis in HepG2 cells.

Abietane diterpenesAntitumor activityCephalotaxaceaeCephalotaxus oliveri Mast.

Jiang C.、Yang M.、Zhao C.、Liu F.、Yang H.、Li Z.、Lin B.、Li D.、Hua H.、Han T.

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Key Laboratory of Structure-Based Drug Design & Discovery Ministry of Education And School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

Department of Pharmaceutical Engineering College of Life Science & Technology Heilongjiang Bayi Agricultural University

2022

10.1016/j.phytochem.2022.113187

Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
年,卷(期)：2022.199
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