Phytochemistry2022，Vol.1998.DOI:10.1016/j.phytochem.2022.113187

Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity

Jiang C. Yang M. Zhao C. Liu F. Yang H. Li Z. Lin B. Li D. Hua H. Han T.
Phytochemistry2022，Vol.1998.DOI:10.1016/j.phytochem.2022.113187
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  • NSTL
  • Elsevier

Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity

Jiang C. 1Yang M. 1Zhao C. 1Liu F. 1Yang H. 1Li Z. 1Lin B. 1Li D. 1Hua H. 1Han T.2
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作者信息

  • 1. Key Laboratory of Structure-Based Drug Design & Discovery Ministry of Education And School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University
  • 2. Department of Pharmaceutical Engineering College of Life Science & Technology Heilongjiang Bayi Agricultural University
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Abstract

? 2022 Elsevier LtdTwenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglyptin A was the most active with IC50 values of 16.34, 15.63 and 21.33 μM and was further investigated for colony formation and apoptosis in HepG2 cells.

Key words

Abietane diterpenes/Antitumor activity/Cephalotaxaceae/Cephalotaxus oliveri Mast.

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出版年

2022
Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
被引量5
参考文献量30
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