首页|Family history of alcohol use disorder is associated with brain structural and functional changes in healthy first-degree relatives

Family history of alcohol use disorder is associated with brain structural and functional changes in healthy first-degree relatives

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  • NSTL
  • Elsevier
Background: Neuroimaging studies of vulnerability to Alcohol Use Disorder (AUD) have identified structural and functional variations which might reflect inheritable features in alcohol-naive relatives of AUD individuals (FH+) compared to controls having no such family history (FH-). However, prior research did not simultaneously account for childhood maltreatment, any clinically significant disorder and maternal AUD. Therefore, we mainly aimed to investigate the brain structure and reward-related neural activations (fMRI), using whole-brain analysis in FH+ young adults with no prevalent confounders.

Alcohol use disorderChildhood Trauma QuestionnaireMonetary Incentive Delay taskRelativesVoxel-Based MorphometryVulnerability

Filippi, Irina、Hoertel, Nicolas、Artiges, Eric、Airagnes, Guillaume、Guerin-Langlois, Christophe、Seigneurie, Anne-Sophie、Frere, Pauline、Dubol, Manon、Guillon, Francois、Lemaitre, Herve、Rahim, Mehdi、Martinot, Jean-Luc、Limosin, Frederic

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Univ Paris 05, Univ Paris Saclay, Univ Paris Sud, Digiteo Labs,INSERM,Unit Neuroimaging & Psychiat

Hop Univ Paris Ouest, AP HP, Dept Psychiat & Addictol, Paris, France

CEA, DSV, I2BM, Neurospin, Gif Sur Yvette, France

2019

10.1016/j.eurpsy.2019.08.003

European psychiatry :

European psychiatry :

ISSN：0924-9338
年,卷(期)：2019.62
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