首页|LncRNA PCAT29 Up-Regulates the Expression of PTEN by Down-Regulating miR-494 in Non-Small-Cell Lung Cancer to Suppress Tumor Progression
LncRNA PCAT29 Up-Regulates the Expression of PTEN by Down-Regulating miR-494 in Non-Small-Cell Lung Cancer to Suppress Tumor Progression
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NSTL
PCAT29 has reported to exert tumor suppressive roles. In this study, we investigated the function of PCAT29 in non-small-cell lung cancer (NSCLC). Expression levels of PCAT29, miR-494, and PTEN in non-tumor and NSCLC tumor tissue samples were measured by performing quantitative reverse transcription polymerase chain reaction. Cell apoptosis and proliferation analyses were formed to study the effects of overexpression of PCAT29, miR-494, and PTEN on apoptosis and proliferation of H23 cells. It was observed that PCAT29 was down-regulated in NSCLC and predicted poor survival. In NSCLC cells, miR-494 was inversely, while PTEN was positively correlated with PCAT29. In NSCLC cells, overexpression of PCAT29 led to down-regulated miR-494 and up-regulated PTEN. Overexpression of miR-494 resulted in down-regulated PTEN but did not affect the expression of PCAT29. Overexpression of PTEN affected neither PCAT29 nor miR-494. In addition, overexpression of PCAT29 and PTEN resulted in increased apop-totic rate and decreased proliferation of NSCLC cells. miR-494 played an opposite role and attenuated the effects of overexpression of PCAT29. Therefore, PCAT29 may up-regulate PTEN by down-regulating miR-494 to suppress the progression of NSCLC cells.
Lu B、Lv H、Yang Z、Shu J、Zhang H
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Department of Respiratory Medicine, Taicang Hospital of Traditional Chinese Medicine, Suzhou
NSTL
