首页|A corrole-based fluorescent probe for detection of sulfur ion and its application in living cells
A corrole-based fluorescent probe for detection of sulfur ion and its application in living cells
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NSTL
A dual signaling probe DPC-O-NBD formed through the conjugation of 5,15-bis(phenyl)-10-(4-hydroxylphenyl)-corrole (DPC-OH) with 4-chloro-7-nitrobe-nzo-2-oxa-l,3-diazole (NBD-C1) is explored to detect sulfur ion (S~(2-)). The key design principle is based on the nucleophilicity of S~(2-), which can be used to cleave the bridging ether bond in the probe to obtain both fluorogenic and chromogenic signaling behaviors. Importantly, the probe DPC-O-NBD not only showed a high sensitivity (LOD: 48 nM) and selectivity over other interfering species, but also exhibited a rapid response (—18 s) towards S~(2-). Furthermore, DPC-O-NBD can also be used to detect S~(2-) in both water and live cells, providing a potentially powerful approach for probing S~(2-) chemistry in biological systems.
NSTL
