首页|Chemical constituents of Ruta graveolens L. and their melanogenic effects and action mechanism
Chemical constituents of Ruta graveolens L. and their melanogenic effects and action mechanism
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NSTL
Elsevier
? 2021 Elsevier B.V.Ruta graveolens L. has been widely used to treat various skin ailments, especially vitiligo. In this study, we isolated a new furanocoumarin named Rutagrarin (1) along with 14 known compounds (2–15) from the aerial parts of R. graveolens and elucidated their chemical structures via various spectroscopy. We found that compound 5 promoted melanogenesis and tyrosinase activity in B16 cells. Further investigation on underlying mechanisms revealed that compound 5 activated the transcription of microtia-related transcription factors and promoted the production of melanin in B16 cells via the Akt/GSK-3β/β-catenin pathway. Therefore, we confirmed the traditional efficacy of R. graveolens and speculated that compound 5 could be used as a natural drug to treat vitiligo.
Zang D.、Jiang L.、Aisa H.A.、Li Y.、Ainiwaer P.、Nueraihemaiti M.、Li Z.
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State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences
NSTL
Elsevier
