首页|Experimental study The effect of 4-Week rehabilitation by aerobic exercise on hippocampus BDNF and TGF-beta 1 gene expressions in A beta 1-42-induced rat model of Alzheimer's disease
Experimental study The effect of 4-Week rehabilitation by aerobic exercise on hippocampus BDNF and TGF-beta 1 gene expressions in A beta 1-42-induced rat model of Alzheimer's disease
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Elsevier
Alzheimer's disease (AD) is a type of brain dysfunction featuring a gradual loss in memory. This study aimed to determine the effect of 4 weeks of aerobic rehabilitation exercise (RhExe) on the genes expression of BDNF and TGF-beta 1 in the hippocampus tissue of rats with the AD induced by injection of amyloid-beta (A beta(1-42)). Twenty-one male Wistar rats were randomly divided into 3 groups: A beta injection (n = 7), A beta + exercise (n = 7) and control (n = 7). AD was induced by a single dose of A beta injection into the hippocampus of rats. Three days after surgery, the A beta + exercise group experienced four weeks of the RhExe (5 days/week). Forty-eight hours after the last training session, the animals underwent the Morris water maze test. The animals were sacrificed 24 h after the test, and hippocampal tissue was split. The mRNA expression of BDNF, TGF-beta 1, and TGF-beta 1 II receptors was measured. The TGF-beta 1 and TGF-beta 1 II receptor genes expression of A beta + exercise group were significantly higher than the A beta injection group (P <= 0.001). BDNF gene expression in the hippocampus of the A beta + exercise group was significantly higher than the A beta injection group (P <= 0.001). Spatial memory was significantly higher in the A beta + exercise group than in the A beta injection group (p <= 0.01). It seems that aerobic exercise can counteract the harmful effects of A beta through the BDNF and TGF-beta 1molecular signaling pathways. (c) 2021 Elsevier Ltd. All rights reserved.
NSTL
Elsevier
