More that ACE2? NRP1 may play a central role in the underlying pathophysiological mechanism of olfactory dysfunction in COVID-19 and its association with enhanced survival
More that ACE2? NRP1 may play a central role in the underlying pathophysiological mechanism of olfactory dysfunction in COVID-19 and its association with enhanced survival
Hopkins, Claire 1Lechien, Jerome R. 2Saussez, Sven2
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作者信息
1. Guys & St Thomas NHS Fdn Trust, London, England
2. COVID 19 Task Force Young Otolaryngologists Int F, Paris, France
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Abstract
Three mechanisms have been proposed to account for COVID-19 associated olfactory dysfunction; obstruction of the olfactory cleft; epithelial injury and infection of the sustentacular supporting cells, which are known to express ACE2, or injury to the olfactory bulb due to axonal transport through olfactory sensory neurones. The absence of ACE2 expression by olfactory sensory neurones has led to the neurotropic potential of COVID-19 to be discounted.
NSTL
Elsevier