首页|More that ACE2? NRP1 may play a central role in the underlying pathophysiological mechanism of olfactory dysfunction in COVID-19 and its association with enhanced survival

More that ACE2? NRP1 may play a central role in the underlying pathophysiological mechanism of olfactory dysfunction in COVID-19 and its association with enhanced survival

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  • NSTL
  • Elsevier
Three mechanisms have been proposed to account for COVID-19 associated olfactory dysfunction; obstruction of the olfactory cleft; epithelial injury and infection of the sustentacular supporting cells， which are known to express ACE2， or injury to the olfactory bulb due to axonal transport through olfactory sensory neurones。 The absence of ACE2 expression by olfactory sensory neurones has led to the neurotropic potential of COVID-19 to be discounted。

COVIDOlfactory lossDisease severityNeurotropismNeuropilin

Hopkins, Claire、Lechien, Jerome R.、Saussez, Sven

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Guys & St Thomas NHS Fdn Trust, London, England

COVID 19 Task Force Young Otolaryngologists Int F, Paris, France

2021

10.1016/j.mehy.2020.110406

Medical hypotheses

Medical hypotheses

SCI
ISSN：0306-9877
年,卷(期)：2021.146
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