首页|Two new metabolites from Portulaca oleracea and their anti-inflammatory activities
Two new metabolites from Portulaca oleracea and their anti-inflammatory activities
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NSTL
Elsevier
? 2022 Phytochemical Society of EuropeTwo new metabolites, identified as 6-phenylbenzofuran-4-ol, named olerabenzofuran (1), and 2-(furan-2-yl)? 6-hydroxy-1 H-inden-1-one, named oleraindenone (2), together with eight furan compounds obtained for the first time, (+)-pinoresinol (3), (-)-syringaresinol (4), (+)-diasyringaresinol (5), (+)-episyringaresinol (6), (2 S)? 1-[2-(furan-2-yl)? 2-oxoethyl]? 5-oxopyrrolidine-2-carboxylic acid (7), methyl (2 S)? 1[2-(furan-2-yl)? 2-oxoethyl]? 5-oxopyrrolidine-2-carboxylate (8), drynaran (9), and 2-furoic acid (10), were isolated from Portulaca oleracea L., and spectroscopic methods, including 1D and 2D NMR and UHPLC-ESI-QTOF/MS spectrometry techniques, were employed to determine their structures. It was suggested that both olerabenzofuran (1) and oleraindenone (2) could significantly inhibit inflammatory factor interleukin-1β (IL-1β) in RAW 264.7 cells induced by LPS.
Anti-inflammatory activityMetabolitesPortulaca oleracea L.
Tian J.、Lan X.、Ying X.、Ying Z.、Li Y.、Leng A.
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School of Pharmacy Liaoning University of Traditional Chinese Medicine
Department of Clinic Laboratory The Second Affiliated Hospital of Dalian Medical University Dalian
Department of Pharmacy The First Affiliated Hospital of Dalian Medical University
NSTL
Elsevier
