Tetrahedron letters2022，Vol.975.DOI:10.1016/j.tetlet.2022.153779

Iridium-catalyzed oxidative coupling and cyclization of NH isoquinolones with olefins leading to isoindolo[2,1-b]isoquinolin-5(7H)-one derivatives

Yan, Kelu Liu, Xiao Liu, Min Wen, Jiangwei Du, Mingyue Fu, Yingxue Chen, Wenxin
Tetrahedron letters2022，Vol.975.DOI:10.1016/j.tetlet.2022.153779
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  • NSTL
  • Elsevier

Iridium-catalyzed oxidative coupling and cyclization of NH isoquinolones with olefins leading to isoindolo[2,1-b]isoquinolin-5(7H)-one derivatives

Yan, Kelu 1Liu, Xiao 1Liu, Min 1Wen, Jiangwei 1Du, Mingyue 1Fu, Yingxue 1Chen, Wenxin1
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作者信息

  • 1. Qufu Normal Univ
  • 折叠

Abstract

The iridium-catalyzed oxidative coupling and cyclization of NH isoquinolones with olefins has been realized. Most isoindolo[2,1-b]isoquinolin-5(7H)-one derivatives were obtained in moderate to good yields. Several derivatization reactions including functional group conversion and further C-H/olefin coupling were also performed. This transformation realized the less developed Cp*Ir(III) catalyzed coupling and cyclization reaction of NH substrates with olefins. (c) 2022 Elsevier Ltd. All rights reserved.

Key words

C-H activation/Iridium/Isoquinolones/Olefins/Isoindolo[2/1-b]isoquinolin-5(7H)-ones/TOPOISOMERASE-I INHIBITORS/C-H ACTIVATION/DIAZO-COMPOUNDS/BOND FORMATION/ANNULATION/ALKYNES/ALKYLATION/BENZAMIDES/RH

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量3
参考文献量62
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