首页|ANTIBACTERIAL NAPHTHALENE DERIVATIVES FROM THE FERMENTATION PRODUCTS OF THE ENDOPHYTIC FUNGUS Phomopsis fukushii
ANTIBACTERIAL NAPHTHALENE DERIVATIVES FROM THE FERMENTATION PRODUCTS OF THE ENDOPHYTIC FUNGUS Phomopsis fukushii
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NSTL
Two new naphthalene derivatives,1-(3-hydroxy-1-(hydroxymethyl)-2-methoxy-6-methylnaphthalen-7-yl)propan-2-one(1)and 1-(3-hydroxy-1-(hydroxymethyl)-6-methylnaphthaIen-7-yl)propan-2-one(2),together three known naphthalene derivatives(3-5)were isolated from the fermentation products of the endophytic fungus Phomopsis fukushii.Their structures were elucidated by spectroscopic methods,including extensive ID and 2D NMR techniques.Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus(anti-MRSA)activity.The results showed that compounds 1 and 2 showed weak inhibition with IZD of 10.2 ± 1.8 and 11.3 ± 2.0 mm,respectively.
NSTL
