Phytochemistry2022，Vol.1947.DOI:10.1016/j.phytochem.2021.112839

Squamins C-F, four cyclopeptides from the seeds of Annona globiflora

Sosa-Rueda, Javier Dominguez-Melendez, Vanihamin Ortiz-Celiseo, Araceli Lopez-Fentanes, Fernando C. Cuadrado, Cristina Fernandez, Jose J. Daranas, Antonio Hernandez Cen-Pacheco, Francisco
Phytochemistry2022，Vol.1947.DOI:10.1016/j.phytochem.2021.112839
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  • NSTL
  • Elsevier

Squamins C-F, four cyclopeptides from the seeds of Annona globiflora

Sosa-Rueda, Javier 1Dominguez-Melendez, Vanihamin 1Ortiz-Celiseo, Araceli 1Lopez-Fentanes, Fernando C. 1Cuadrado, Cristina 2Fernandez, Jose J. 3Daranas, Antonio Hernandez 2Cen-Pacheco, Francisco1
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作者信息

  • 1. Veracruz Univ
  • 2. Inst Prod Nat & Agrobiol CSIC IPNA CSIC
  • 3. Univ La Laguna
  • 折叠

Abstract

Four cyclic octapeptides, squamins C-F, were isolated from the seeds of Annona globiflora Schltdl. These compounds share part of their amino acid sequence, -Pro-Met(O)-Tyr-Gly-Thr-, with previously reported squamins A and B. Their structures were determined using NMR spectroscopic techniques together with quantum mechanical calculations (QM-NMR), ESI-HRMS data and a modified version of Marfey's chromatographic method. All compounds showed cytotoxic activity against DU-145 (human prostate cancer) and HeLa (human cervical carcinoma) cell lines. Clearly, A. globiflora is an important source of bioactive molecules, which could promote the sustainable exploitation of this undervalued specie.

Key words

Annona globiflora Schltdl/Annonaceae/Cyclopeptides/Cytotoxic activity/DIASTEREOISOMERS/STEREOCHEMISTRY/CONFIGURATION

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出版年

2022
Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
被引量1
参考文献量27
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