首页|A regenerable and reducing false-positive fluorescent switch for detection of β-amyloid 1?42 oligomers
A regenerable and reducing false-positive fluorescent switch for detection of β-amyloid 1?42 oligomers
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NSTL
Elsevier
? 2022 Elsevier B.V.The conventional fluorescence analysis methods for disease identification are vulnerable to the restriction with false-positive. Here, a fluorescent switch with high efficiency and regeneration by the black phosphorus (BP) nanosheets-regulated was developed to overcome false-positive issue in the assay of β-amyloid1?42 oligomers (Aβ) process. The Aβ was rapidly recognized using the fluorescent emitter‐nitrogen-doped carbon nanodots (N-CDs) under the regulation of BP nanosheets, while the N-CDs alone cannot recognize Aβ without the introduction of BP. The fluorescence analysis methods exhibited a wide sensing range of 0.25–15.0 ng/mL and a low detection limit of 83 pg/mL for Aβ analysis, which was superior to the reported fluorescence analysis method. Further, BP nanosheets were recycled, demonstrating the fluorescent switch with highly efficient, stable, and regenerable. This provides a new idea for developing high-efficiency and high-precision fluorescence detection platform.
BP nanosheetsFluorescent switchReducing false-positiveRegenerable
Tan S.、Li S.、Qu Q.、Li L.、Yang L.、Ran X.、Tang C.、Bai X.
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School of Chemical Science and Technology Yunnan University
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan University
International Joint Research Center for Biomass Materials Yunnan Province Key Lab of Wood Adhesives and Glued Products College of Materials Science and Engineering Southwest Forestry University
College of Chemical Engineering Southwest Forestry University
NSTL
Elsevier
