首页|Using clinical patient characteristics to predict treatment outcome of cognitive behavior therapies for individuals with medically unexplained symptoms: A systematic review and meta-analysis

Using clinical patient characteristics to predict treatment outcome of cognitive behavior therapies for individuals with medically unexplained symptoms: A systematic review and meta-analysis

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  • NSTL
  • Elsevier
Objective: For individuals with medically unexplained symptoms (MUS), cognitive behavioral therapy (CBT) is the best-evaluated treatment. This systematic review and meta-analyses identify clinical patient characteristics associated with the treatment outcome of CBT for MUS. Methods: A systematic literature search (PubMed, PsycInfo, Web of Science) resulted in 53 eligible studies; of these 32 studies could be included in meta-analyses. Pooled correlation coefficients between predictors and treatment outcome were calculated with a random-effects model. Moderator analyses were conducted to examine differences between subgroups of MUS and different levels of methodological study quality. Results: Meta-analyses demonstrated that individuals with higher symptom intensity (r = 0.38; p < 0.001), lower physical functioning (r = -0.29; p < 0.001), lower emotional and social functioning (r = -0.37; p < 0.001), more potential symptom-related incentives (r = -0.15; p = 0.001), or longer symptom duration (r = 0.10; p = 0.033) at the beginning of treatment reported less change of symptom severity until the end of therapy or higher end-of treatment symptom severity. The pooled effect sizes did not differ between certain subgroups of MUS or between different levels of methodological quality. Conclusion: Our findings indicated that clinical characteristics of MUS patients are associated with treatment outcome of CBT. We discuss how the results can be used to optimize and personalize future treatments for MUS.

Cognitive behavior therapySomatic symptom disorderMedically unexplained symptomsFunctional somatic syndromesPredictorOutcomeCHRONIC-FATIGUE-SYNDROMEIRRITABLE-BOWEL-SYNDROMEFUNCTIONAL SOMATIC SYNDROMESSOMATOFORM DISORDERSCHRONIC PAINFUNNEL-PLOTBIASDEPRESSIONFIBROMYALGIADISABILITY

Sarter, Lena、Heider, Jens、Witthoft, Michael、Rief, Winfried、Kleinstauber, Maria

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Philipps University Marburg,Philipps Univ Marburg

Dept Clin Psychol & Psychotherapy,Univ Koblenz Landau

Dept Clin Psychol Psychotherapy & Expt Psychopatho,Johannes Gutenberg Univ Mainz

Emma Eccles Jones Coll Educ & Human Serv,Utah State Univ

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2022

10.1016/j.genhosppsych.2022.03.001

General hospital psychiatry

General hospital psychiatry

SCI
ISSN：0163-8343
年,卷(期)：2022.77
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