首页|Thermlanseedlines A–G, seven thermopsine-based alkaloids with antiviral and insecticidal activities from the seeds of Thermopsis lanceolata R. Br.

Thermlanseedlines A–G, seven thermopsine-based alkaloids with antiviral and insecticidal activities from the seeds of Thermopsis lanceolata R. Br.

扫码查看
原文链接
  • NSTL
  • Elsevier
? 2022 Elsevier B.V.Seven undescribed thermopsine-based alkaloids (1–7), including one undescribed biogenetically related intermediate (7), were isolated from the seeds of Thermopsis lanceolata R. Br. Compound 1 possessed a 6/6–6 tricyclic skeleton, while compounds 2–6 represented three rare dimerization patterns constructed by quinolizidine alkaloids. Their structures were elucidated by comprehensive spectroscopic data analysis as well as ECD calculations. Biologically, compound 6 displayed significant anti-Tomato spotted wilt virus (TSWV) activity compared with the positive control ningnanmycin. Moreover, compound 1 exhibited good insecticidal activity against Aphis fabae with LC50 value of 25.2 mg/L.

Anti-TSMVInsecticidal activityQuinolizidine alkaloidsThermopsis lanceolata R. Br.

Yuan C.-M.、Gu W.、Zhang Y.、Huang L.-J.、Hu Z.-X.、Hao X.-J.、Cui Y.、Zhao L.-H.、Zhang P.、An Q.、Yi P.、Zou J.-B.

展开 >

State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University

State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Science

The Institute of Biotechnology and Germplasm Resources Yunnan Academy of Agricultural Sciences

2022

10.1016/j.fitote.2022.105140

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2022.158
  • 3
  • 31