Fitoterapia2022，Vol.1589.DOI:10.1016/j.fitote.2022.105140

Thermlanseedlines A–G, seven thermopsine-based alkaloids with antiviral and insecticidal activities from the seeds of Thermopsis lanceolata R. Br.

Yuan C.-M. Gu W. Zhang Y. Huang L.-J. Hu Z.-X. Hao X.-J. Cui Y. Zhao L.-H. Zhang P. An Q. Yi P. Zou J.-B.
Fitoterapia2022，Vol.1589.DOI:10.1016/j.fitote.2022.105140
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  • NSTL
  • Elsevier

Thermlanseedlines A–G, seven thermopsine-based alkaloids with antiviral and insecticidal activities from the seeds of Thermopsis lanceolata R. Br.

Yuan C.-M. 1Gu W. 1Zhang Y. 2Huang L.-J. 1Hu Z.-X. 1Hao X.-J. 1Cui Y. 3Zhao L.-H. 3Zhang P. 1An Q. 1Yi P. 1Zou J.-B.1
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作者信息

  • 1. State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University
  • 2. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Science
  • 3. The Institute of Biotechnology and Germplasm Resources Yunnan Academy of Agricultural Sciences
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Abstract

? 2022 Elsevier B.V.Seven undescribed thermopsine-based alkaloids (1–7), including one undescribed biogenetically related intermediate (7), were isolated from the seeds of Thermopsis lanceolata R. Br. Compound 1 possessed a 6/6–6 tricyclic skeleton, while compounds 2–6 represented three rare dimerization patterns constructed by quinolizidine alkaloids. Their structures were elucidated by comprehensive spectroscopic data analysis as well as ECD calculations. Biologically, compound 6 displayed significant anti-Tomato spotted wilt virus (TSWV) activity compared with the positive control ningnanmycin. Moreover, compound 1 exhibited good insecticidal activity against Aphis fabae with LC50 value of 25.2 mg/L.

Key words

Anti-TSMV/Insecticidal activity/Quinolizidine alkaloids/Thermopsis lanceolata R. Br.

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
被引量3
参考文献量31
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