首页|Six C21 steroidal glycosides from Cynanchum wallichii Wight roots and their multidrug resistance reversal activities
Six C21 steroidal glycosides from Cynanchum wallichii Wight roots and their multidrug resistance reversal activities
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NSTL
Elsevier
? 2022 Elsevier LtdSix unidentified C21 steroidal glycosides, cynwallosides A?F, as well as twenty-two known compounds, were isolated from the roots of Cynanchum wallichii Wight. The structures of cynwallosides A?F were determined by spectroscopic analysis and acidic hydrolysis. Most of these twenty-eight compounds were found to significantly reverse drug resistance in both the MCF-7/ADR and HepG2/ADM cell lines by suppressing P-gp protein expression. Further investigation revealed that three compounds suppressed P-gp expression by significantly inactivating the JNK and NF-κB pathways.
Liu Z.、Lu L.、Zhang R.-R.、Zhang L.、Yuefang L.、min H.、Wenbo C.、Duan L.
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Joint Laboratory for Translational Cancer Research on Chinese Medicine of the Ministry of Education of the People's Republic of China International Institute for Translational Chinese Medicine School of Pharmaceutical Sciences Guangzhou University of Chin
NSTL
Elsevier
