首页|Hybrid NaYF4:Er,Yb@NaYF4@nano-MOF@AuNPs@LB composites for Yb3+-Er3+ physiological thermometry
Hybrid NaYF4:Er,Yb@NaYF4@nano-MOF@AuNPs@LB composites for Yb3+-Er3+ physiological thermometry
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NSTL
Elsevier
UiO-66-NH2 is a well-known Zr-MOF with a high surface area and good chemical stability, which is often employed for catalysis. The biological applications of Zr-MOFs are less often explored, however it has already been shown that they can be used for drug loading and release. In this work we show that UiO-66-NH2 (referred to as nano-MOF throughout the work) can be a host for accommodating beta-NaYF4:Er,Yb@beta-NaYF4 nano thermometers as well as gold nanoparticles (AuNPs) which can potentially take on the role of nanoheaters for plasmon-induced hyperthermia. Such a hybrid material can be made in an easy two step approach and yields nano-sized porous composites. At the same time, it could potentially still be used for drug delivery. A lipid bilayer is wrapped around the nano-MOF composites to further improve their biocompatibility with the human body. The hybrid composite shows good thermometry in the physiological range when dispersed in water.
NSTL
Elsevier
