Divirensols: Sesquiterpene Dinners from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16
Salim, Angela A. 1Lin, Hou-Wen 2Jiao, Wei-Hua 1Capon, Robert J. 1Dewapriya, Pradeep 1Mohamed, Osama 1Khalil, Zeinab G.1
扫码查看
点击上方二维码区域，可以放大扫码查看
作者信息
1. Univ Queensland, Inst Mol Biosci, Div Chem & Struct Biol, St Lucia, Qld 4072, Australia
2. Shanghai Jiao Tong Univ, Ren Ji Hosp, State Key Lab Oncogenes & Related Genes, Res Ctr Marine Drugs,Dept Pharm,Sch Med, Shanghai 200127, Peoples R China
折叠
Abstract
A chemical investigation of the Australian termite nest-derived fungus Trichoderma virens CMB-TN16 yielded the known sesquiterpene gliocladic acid (1), together with two new acetylated analogues, 3-acetylgliocladic acid (2) and 14-acetylgliocladic acid (3), and seven new dimeric congeners, divirensols A G (4-10). All metabolites were identified by detailed spectroscopic analysis, supported by biosynthetic considerations, and were assessed for antibacterial and cytotoxic properties. The divirensols are examples of an exceptionally rare class of dimeric sesquiterpene, likely linked via a highly convergent biosynthetic pathway. HPLC-DAD-MS analysis of the crude fungal extract detected ions attributed to putative monomeric biosynthetic precursors.
NSTL
Amer Chemical Soc