首页|Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A

Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A

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  • NSTL
  • Elsevier
? 2021 Phytochemical Society of EuropeTwo new azaphilones, penicilazaphilones F (1) and G (2) together with two known analogs (3 and 4), were isolated from fermentation cultures of the marine-derived fungus Penicillium sclerotiorum E23Y-1A. Their structures were elucidated based on spectroscopic methods, including IR, MS, 1D and 2D NMR, as well as by comparison with published data. The absolute configuration of compound 1 was unambiguously determined using electronic circular dichroism (ECD) calculation. All isolated compounds were evaluated for their anti-inflammatory effects. Compounds 1-4 inhibited the lipopolysaccharide-induced production of nitric oxide (NO) in BV-2 cells, with IC50 values of 31.7 ± 1.5, 34.5 ± 1.4, 25.3 ± 2.2, and 34.8 ± 1.9 μM, respectively. In contrast, these compounds showed no obvious cytotoxicity at a concentration of 50.0 μM.

Anti-inflammatoryAzaphiloneMarine-derived fungusMetabolitePenicillium sclerotiorum

Yin J.、Zhao X.、Mao Y.、Zeng Y.、Wang S.、Chang W.

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School of Life Science and Engineering Lanzhou University of Technology

Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences

2022

10.1016/j.phytol.2021.11.006

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.47
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