Abstract
Organocatalysis by the combination of weak acids, namely, 2,20-biphenol and B(OH)3, for 2-aza-Cope rearrangement is described. Aldehydes and 1,1-diphenyl homoallylamine were converted into the corre-sponding homoallylamines in moderate-to-high yield in the presence of 10 mol% 2,20-biphenol and 30 mol% B(OH)3. In contrast to the conventional 2-aza-Cope rearrangement catalyzed by strong activa-tors, a user-and environment-friendly organocatalytic system was established using a combination of inexpensive, easy-to-handle, non-hazardous, and bench-stable reagents.(c) 2022 Elsevier Ltd. All rights reserved.
NSTL
Elsevier