首页|Design and preparation of a biomedical titanium alloy with low elastic modulus and high antibacterial property based on Ti-Mo-Ag system
Design and preparation of a biomedical titanium alloy with low elastic modulus and high antibacterial property based on Ti-Mo-Ag system
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NSTL
Elsevier
? 2022 Elsevier B.V.Titanium and titanium alloys have been widely used as biomedical materials as a result of low density, high specific strength, good biological propertise, good mechanical compatibility and easy processing. However, problems such as stress shielding and bacterial infection often occur in the clinical application. In this paper, Ti-15Mo-xAg (x = 10, 12) alloys were designed and prepared to obtain low elastic modulus and excellent antibacterial ability. We studied the microstructure, mechanical properties, antibacterial properties and cytocompatibility by scanning electron microscopy, differential scanning calorimeter, X-ray diffraction, micro-hardness instrument and plate counting method. The calculated results indicated that Ti-15Mo alloys with different Ag contents could be β-type or near β-type alloy with potential of a low elastic modulus. Microstructure results demonstrated that the increasing Ag content from 10 wt% to 12 wt% increased the phase transformation temperature and resisted the formation of ω phase in Ti-Mo-Ag system. Both the elastic modulus and the antibacterial ability were significantly influenced by the ageing treatment and Ag content due to the phase constitution, and high Ag content and the precipitation of Ti2Ag were beneficial to the antibacterial performance but increased the elastic modulus. Cell assessment showed that Ti-Mo-Ag alloys did not have cytotoxicity to MC3T3. Ti-15Mo-10Ag alloy exhibited strong antibacterial rate of 99.5%, good cellular compatibility and low elastic modulus of 85 GPa, which suggests that this alloy might be a highly competitive medical material.
Cui S.、Liu S.、Qin G.、Zhang E.、Nie J.、Chen D.、Wu X.
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Key Lab. for Anisotropy and Texture of Materials Education Ministry of China School of Materials Science and Engineering Northeastern University
Laboratory of Bone tissue engineering Beijing Laboratory of biomedical materials Beijing Research Institute of Orthopaedics and Traumatology Beijing Jishuitan Hospital
Department of Orthopedic Trauma Beijing Jishuitan Hospital
NSTL
Elsevier
