首页|Together is better: poly(tannic acid) nanorods functionalized polysaccharide hydrogels for diabetic wound healing
Together is better: poly(tannic acid) nanorods functionalized polysaccharide hydrogels for diabetic wound healing
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NSTL
Elsevier
? 2022 Elsevier B.V.Polysaccharide hydrogel dressings are strong candidates for wound healing due to their low-cost, adsorbable, biodegradable, and biocompatible features. However, they may have some drawbacks, such as static properties, weak mechanics, and the inability to fully meet the requirements of the different phases of wound repair. Enhanced functionality achieved by incorporating nanomaterials into traditional polysaccharide networks is an effective way to address these challenges. Herein, an all-in-one hydrogel dressing (OQP2) that possessed hemostasis, antibacterial, reactive oxygen species scavenging, and angiogenic properties was readily synthesized by introducing poly(tannic acid) nanorods into a polysaccharide matrix comprising oxidized β-glucan and quaternary ammonium chitosan. As expected, the OQP2 can accelerate wound healing in diabetic rat models. This study offers a convenient and facile one-pot strategy to construct multifunctional polysaccharide hydrogel dressings for treating diabetic wounds.
Diabetic wound healingHydrogel dressingsPoly(tannic acid) nanorodsPolysaccharidesReactive oxygen species scavenging
You S.、Shen J.、Qi X.、Mao R.、Xiang Y.、Cai E.、Huang Y.、Chen Y.、Dong W.
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State Key Laboratory of Ophthalmology Optometry and Vision Science School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University
School & Hospital of Stomatology Wenzhou Medical University
School of Chemical Engineering Nanjing University of Science & Technology
NSTL
Elsevier
