首页|Sleep disorders and neuropsychiatric disorders in a pediatric sample of tuberous sclerosis complex: a questionnaire-based study

Sleep disorders and neuropsychiatric disorders in a pediatric sample of tuberous sclerosis complex: a questionnaire-based study

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  • NSTL
  • Elsevier
? 2021 The Author(s)Objective and background: Sleep disorders (SD) are very common in childhood, especially in certain genetic syndromes. Tuberous Sclerosis Complex (TSC) is a genetic syndromesassociated with a high rate of SD, although these are still under-recognized. The aim of this study was to assess the prevalence of SD in TSC, and to evaluate the relationship between sleep, epilepsy and TSC-associated neuropsychiatric disorders (TAND). Methods: We administered the Sleep Disturbance Scale for Children (SDSC) and the Epworth Sleepiness Scale for Children and Adolescents (ESS-CHAD) to parents of 177 children with TSC referring to different Italian centers. We also collected information on epilepsy and TAND. Results: SDSC score was positive in 59.3% of patients, being positive in 30.4% of patients without and in 63.6% of those with epilepsy (p = 0.005). However, in a multivariate logistic model considering antiseizure medications and nocturnal seizures, epilepsy ceased to be a significant risk factor for positive SDSC (OR = 2.4; p = 0.17). As for TAND, SDSC was positive in 67.9% of patients with and in 32.5% of those without TAND (p < 0.001). After adding in a multivariate logistic model active epilepsy, age, and pharmacotherapies, TAND continued to be a significant risk factor for positive SDSC (p = 0.01, OR = 1.11). Conclusions: Our results revealed a high prevalence of SD in children with TSC. Epilepsy didn't increase the risk for SD, while a very strong association was found with TAND. An early detection of SD is of utmost importance in order to plan an individualized treatment, that in some cases might also ameliorate behavior and attention.

AutismEpilepsyNeuropsychiatric disordersSleepSleep disordersTuberous sclerosis

Moavero R.、Voci A.、La Briola F.、Matricardi S.、Toldo I.、Mancardi M.M.、Negrin S.、Messana T.、Mazzone L.、Valeriani M.、Curatolo P.、Bruni O.

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Child Neurology and Psychiatry Unit Tor Vergata University of Rome

Child Neuropsychiatry Unit – Epilepsy Center ASST SS. Paolo e Carlo San Paolo Hospital

Child Neurology and Psychiatry Unit Children's Hospital “G. Salesi” Ospedali Riuniti Ancona

Pediatric Neurology and Neurophysiology Unit Department of Woman's and Child Health Padua

Unit of Child Neuropsichiatry Department of Clinical and Surgical Neurosciences and Rehabilitation

Epilepsy and Clinical Neurophysiology Unit Scientific Institute IRCCS Eugenio Medea

IRCCS Istituto Delle Scienze Neurologiche UOC Neuropsichiatria Dell'età Pediatrica

Child Neurology Unit Neuroscience Department Bambino Gesù Children's Hospital IRCCS

Department of Developmental and Social Psychology Sapienza University

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2022

10.1016/j.sleep.2021.11.010

Sleep medicine

Sleep medicine

SCI
ISSN：1389-9457
年,卷(期)：2022.89
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