首页|Towards a PBMC "virogram assay" for precision medicine: Concordance between ex vivo and in vivo viral infection transcriptomes

Towards a PBMC "virogram assay" for precision medicine: Concordance between ex vivo and in vivo viral infection transcriptomes

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  • NSTL
  • Elsevier
Background: Understanding individual patient host-response to viruses is key to designing optimal personalized therapy. Unsurprisingly, in vivo human experimentation to understand individualized dynamic response of the transcriptome to viruses are rarely studied because of the obvious limitations stemming from ethical considerations of the clinical risk.

Personal transcriptomeRhinovirusPBMCGenomic responseVirogramSimilarity Venn Diagrams

Gardeux, Vincent、Bosco, Anthony、Li, Jianrong、Halonen, Marilyn J.、Jackson, Daniel、Lussier, Yves A.、Martinez, Fernando D.

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Univ Arizona, Dept Med, Tucson, AZ 85721 USA

Telethon Inst Child Hlth Res, Perth, WA, Australia

Univ Arizona, Dept Pharmacol, Tucson, AZ 85721 USA

Univ Wisconsin, Dept Pediat, Sch Med & Publ Hlth, Madison, WI USA

Univ Arizona, Dept Pediat, Tucson, AZ 85721 USA

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2015

10.1016/j.jbi.2015.03.003

Journal of biomedical informatics.

Journal of biomedical informatics.

ISSN：1532-0464
年,卷(期)：2015.55
  • 6
  • 34