首页|Discovery of Undescribed Monoterpenoid Polyprenylated Acylphloroglucinols with Immunosuppressive Activities from Hypericum longistylum

Discovery of Undescribed Monoterpenoid Polyprenylated Acylphloroglucinols with Immunosuppressive Activities from Hypericum longistylum

扫码查看
原文链接
  • NSTL
  • Elsevier
Acylphlorostylums A-G (1-7), seven undescribed monoterpenoid polyprenylated acylphloroglucinols, were isolated and identified from Hypericum longistylum. Significantly, acylphlorostylums A and B were the first monoterpenoid polyprenylated acylphloroglucinols possessing a dodecahydro-1H-benzo [b]cyclopenta [e]oxepine moiety bearing a 6/7/5 fused tricyclic ring system that assembled by the attack from 4-OH to C-13. In addition, acylphlorostylums A-G exhibited moderate in vitro immunosuppressive activity in anti-CD3/anti-CD28 monoclonal antibodies, lipopolysaccharide and concanavalin A-induced murine splenocyte proliferation, with IC50 values ranging from 1.51 +/- 0.12 to 18.49 +/- 1.67 mu M, underscoring those isolates as novel chemical templates in the development of novel immunosuppressors.

Hypericum longistylumClusiaceaeMonoterpenoid polyprenylated & nbspacylphloroglucinolsStructural elucidationImmunosuppressive activityChemical calculationA-C

Shi, Zhengyi、Tan, Xiaosheng、Hu, Hong、Zhang, Na、Duan, Yulin、Guo, Yi、Feng, Hao、Sun, Lingjuan、Chen, Gang、Qi, Changxing、Zhang, Yonghui

展开 >

Huazhong Univ Sci & Technol

Chinese Acad Med Sci

2022

10.1016/j.phytochem.2022.113173

Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
年,卷(期)：2022.198
  • 4
  • 20