Phytochemistry2022，Vol.1988.DOI:10.1016/j.phytochem.2022.113173

Discovery of Undescribed Monoterpenoid Polyprenylated Acylphloroglucinols with Immunosuppressive Activities from Hypericum longistylum

Shi, Zhengyi Tan, Xiaosheng Hu, Hong Zhang, Na Duan, Yulin Guo, Yi Feng, Hao Sun, Lingjuan Chen, Gang Qi, Changxing Zhang, Yonghui
Phytochemistry2022，Vol.1988.DOI:10.1016/j.phytochem.2022.113173
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  • NSTL
  • Elsevier

Discovery of Undescribed Monoterpenoid Polyprenylated Acylphloroglucinols with Immunosuppressive Activities from Hypericum longistylum

Shi, Zhengyi 1Tan, Xiaosheng 2Hu, Hong 1Zhang, Na 1Duan, Yulin 1Guo, Yi 1Feng, Hao 2Sun, Lingjuan 2Chen, Gang 2Qi, Changxing 1Zhang, Yonghui1
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作者信息

  • 1. Huazhong Univ Sci & Technol
  • 2. Chinese Acad Med Sci
  • 折叠

Abstract

Acylphlorostylums A-G (1-7), seven undescribed monoterpenoid polyprenylated acylphloroglucinols, were isolated and identified from Hypericum longistylum. Significantly, acylphlorostylums A and B were the first monoterpenoid polyprenylated acylphloroglucinols possessing a dodecahydro-1H-benzo [b]cyclopenta [e]oxepine moiety bearing a 6/7/5 fused tricyclic ring system that assembled by the attack from 4-OH to C-13. In addition, acylphlorostylums A-G exhibited moderate in vitro immunosuppressive activity in anti-CD3/anti-CD28 monoclonal antibodies, lipopolysaccharide and concanavalin A-induced murine splenocyte proliferation, with IC50 values ranging from 1.51 +/- 0.12 to 18.49 +/- 1.67 mu M, underscoring those isolates as novel chemical templates in the development of novel immunosuppressors.

Key words

Hypericum longistylum/Clusiaceae/Monoterpenoid polyprenylated & nbsp/acylphloroglucinols/Structural elucidation/Immunosuppressive activity/Chemical calculation/A-C

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出版年

2022
Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
被引量4
参考文献量20
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