首页|A new coumarin from the fruits of Coutarea hexandra.
A new coumarin from the fruits of Coutarea hexandra.
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
A new 5-O-beta-D-glucopyranosyl-4-(4-hydroxyphenyl)-7-methoxy-2H-chromen-2-one (1), together with four known compounds, one coumarin, 5-O-beta-D-galactopyranosyl-4-(4-hydroxyphenyl)-7-methoxy-2H-chromen-2-one (2) and three cucurbitacins, 23,24-dihydrocucurbitacin F (3), 23,24-dihydro-25-acetylcucurbitacin F (4) and 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin F (5) have been isolated and characterised from the ethanol extract of Coutarea hexandra fruits. Their structures have been established by spectroscopic analysis (NMR and MS). Interpretation of the HMQC, HMBC, COSY-45 and NOESY experiments permitted us to establish stereochemistry of the natural products. All compounds were tested in cytotoxicity assays against the breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.
Centro de Investigaciones Farmacognosticas de la Flora Panamena (CIFLORPAN), Facultad de Farmacia, Universidad de Panama, Panama 0824-00172, Republica de Panama.
NSTL
