首页|Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid
Antinociceptive effect of Lafoensia pacari A. St.-Hil. independent of anti-inflammatory activity of ellagic acid
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Springer Nature
This study was performed to determine the antinociceptive and anti-inflammatory activities of etha-nolic extract of Lafoensia pacari A. St.-Hil. (PEtExt) stem bark and its fractions using various animal models such as acetic acid-induced abdominal writhing, formalin-induced pain and croton oil-induced ear edema tests. The PEtExt inhibited the acetic acid-induced abdominal writhing, reduced the pain reaction time on both phases of the formalin test and decreased the edema in a dose-dependent manner. Pre-treatment with naloxone did not reverse the antinociceptive effect. Only the ethyl acetate fraction showed antinociceptive and anti-inflammatory effects. Our results also showed that this extract contains compounds with analgesic action independent of anti-inflammatory activity.
Medicinal plantsAnalgesic activityBioactivity-guided fractionationNeurogenic painFormalin test
Marcus Vinicius Mariano Nascimento、Pablinny Moreira Galdino、Iziara Ferreira Florentino、Bruno Leite Sampaio、Frederico Argollo Verlinde、Jose Realino de Paula、Elson Alves Costa
展开 >
Laboratorio de Farmacologia de Produtos Naturais, Sala 216, Institute de Ciencias Biologicas-2
NSTL
Springer Nature
