首页|Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents

Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents

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  • NSTL
  • Elsevier
Cyclophilin A (CypA) is linked to diverse human diseases including viral infections. With the worldwide emergence of posing has been highlighted as a strategy with the potential to speed up antiviral development. Because CypA acts as a proviral component in hepatitis C virus, coronavirus and HIV, its inhibitors have been suggested as potential treatments for these infections. Here, we review the structure of cyclosporin A and sanglifehrin A analogs as well as synthetic micromolecules inhibiting CypA; and we discuss their broad-spectrum antiviral efficacy in the context of the virus lifecycle.

Cyclophilin AAntiviralDrug repurposingCyclosporin ADebio-025IMMUNODEFICIENCY-VIRUS TYPE-1INFLUENZA-A VIRUSSTRUCTURE-BASED DISCOVERYHEPATITIS-CCYCLOSPORINE-ACRYSTAL-STRUCTUREBIOLOGICAL EVALUATIONNUCLEAR EXPORTM1 PROTEINCHEMICAL INHIBITORS

Han, Jinhe、Lee, Myoung Kyu、Jang, Yejin、Cho, Won-Jea、Kim, Meeheyin

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Coll Pharm,Chonnam Natl Univ

Infect Dis Therapeut Res Ctr,Korea Res Inst Chem Technol KRICT

2022

10.1016/j.drudis.2022.05.016

Drug discovery today

Drug discovery today

SCI
ISSN：1359-6446
年,卷(期)：2022.27(7)
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