首页|Effect of cerebrospinal fluid drainage on clinical outcomes following aneurysmal subarachnoid hemorrhage
Effect of cerebrospinal fluid drainage on clinical outcomes following aneurysmal subarachnoid hemorrhage
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NSTL
Elsevier
Objectives: We study the relationship between external ventricular drainage (EVD) of cerebrospinal fluid output and functional outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: A retrospective chart review of patients presenting to a single center with aSAH was performed. The primary outcome was good functional outcomes assessed by a composite of the modified Rankin scale (mRS 0-2) at last follow-up. Secondary outcomes were clinical and radiographic vasospasm. For data analysis, multivariable generalized estimating equations adjusting for potential confounders were used. Results: A total of 119 patients were included; 91 (75.6%) presented with a modified Fisher grade 4 and 76 (63.9%) had hydrocephalus. The median EVD duration was 13 days. On average, most EVDs were set at 15 cmH2O (50, 42%). Follow-up was available in 109 patients; median time was 10.7 months; 69 (63.3%) had good outcomes. Multivariable analysis showed that EVDs set at 10 cmH2O had increased odds of good outcomes for every ml increase in the EVD output (OR = 1.02; 95% CI 1.01-1.03; p = 0.001). Post estimation analyses show that EVDs at 10 cmH2O with output close to 200 ml predicted a 50% probability of good outcomes. Conclusions: Increased EVD outputs were associated with favorable outcomes at the last follow-up. (c) 2022 Elsevier Ltd. All rights reserved.
Ascanio, Luis C.、Gupta, Raghav、Tachie-Baffour, Yaw、Chida, Kohei、Dmytriw, Adam A.、Enriquez-Marulanda, Alejandro、Chinnadurai, Anu、Alturki, Abdulrahman Y.、Ogilvy, Christopher S.、Thomas, Ajith J.、Moore, Justin M.
NSTL
Elsevier
