首页|Experimental confirmation of antimicrobial effects of GdYVO4:Eu3+ nanoparticles
Experimental confirmation of antimicrobial effects of GdYVO4:Eu3+ nanoparticles
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NSTL
Taylor & Francis
Nanotechnology can be applied to design antibacterial agents to combat antibiotic resistance。 The aim of the present study was to assess the antimicrobial effects and cytotoxicity of GdYVO4:Eu3+ nanoparticles (NPs)。 Biofilm inhibition activity， antimicrobial activity， bacterial viability inhibition and DNA cleavage activity of GdYVO4:Eu3+ NPs were studied。 In addition， the impact of GdYVO4:Eu3+ NPs on the mitochondrial membrane potential (Delta psi(M)) of host immune cells and， hence， their apoptosis was analyzed by JC-1 staining using flow cytometry。 GdYVO4:Eu3+ NPs demonstrated good antimicrobial， cell viability inhibition and DNA cleavage activities。 In addition， GdYVO4:Eu3+ NPs showed good biofilm inhibition activity against S。 aureus and P。 aeruginosa and inhibition percentages were 89。15% and 79。54%， respectively。 However， GdYVO4:Eu3+ NPs promoted mitochondrial depolarization and apoptosis of leukocytes at high concentrations。 GdYVO4:Eu3+ nanoparticles are promising antibacterial agents。 However， more efforts should be exerted to ensure their safety。
NSTL
Taylor & Francis
